Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diffusion on Chromatography Columns

Diffusion on Chromatography Columns

In column chromatography, when an analyte is introduced as a narrow band at the top of the column, the solutes begin to separate and broaden, developing a Gaussian profile. This broadening occurs due to various factors, such as longitudinal diffusion.
Longitudinal diffusion occurs when the solute molecules in the mobile phase diffuse from the more concentrated center of the chromatographic band to the more dilute regions on either side, both towards and against the flow direction. This...

Analyte Adsorption and Distribution

Analyte Adsorption and Distribution

In certain chromatographic separations, solutes transfer between the mobile phase and the stationary phase via sorption, which typically refers to the process of adsorption. For many chromatographic systems, the sorption process often depends on the polarity of the compounds—an expression of the overall dipole moment within the molecule. During the separation process, there is competition between the solute and solvent for adsorption to the stationary phase. Highly polar compounds and solvents...

Passive Diffusion: Overview and Kinetics

Passive Diffusion: Overview and Kinetics

Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting their diffusion into...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Recent advances in carbon based anti-icing materials: new insights from Hansen Solubility Parameter analysis.

Advances in colloid and interface science·2026

Same author

Carbon nanotube-enabled coatings for advanced anti-icing and deicing applications.

Materials horizons·2025

Same author

Only-sp<sup>2</sup> nanocarbon superhydrophobic materials - Synthesis and mechanisms of high-performance.

Advances in colloid and interface science·2024

Same author

Covalent functionalization of 1D and 2D sp<sup>2</sup>-carbon nanoallotropes - twelve years of progress (2011-2023).

Nanoscale·2024

Same author

Surface-Constrained Metropolis Monte Carlo: Simulation of Reactions on Triply Periodic Minimal Surfaces.

The journal of physical chemistry. A·2024

Same author

Shape-Controlled Iron-Paraffin Composites as γ- and X-ray Shielding Materials Formable by Warmth-of-Hands-Derived Plasticity.

ACS applied engineering materials·2023

Search research articles

Related Experiment Video

Updated: Jul 14, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

Effective diffusion coefficient determination within cylindrical granules of adsorbents using a direct simulation

Zimei Rong¹, Artur P Terzyk, Piotr A Gauden

¹IRC in Biomedical Materials, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom. z.rong@qmul.ac.uk

Journal of Colloid and Interface Science

|June 1, 2007

Summary

This study applies Fick's Second Law to determine solute diffusion coefficients in activated carbon. A simulation method refines initial estimates using experimental adsorption data, accounting for noise and system variables.

More Related Videos

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

Related Experiment Videos

Last Updated: Jul 14, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

Area of Science:

Physical Chemistry
Materials Science
Chemical Engineering

Background:

Analytical models exist for solute adsorption kinetics in porous adsorbents, assuming diffusion is rate-limiting.
These models rely on Fick's Second Law for effective diffusion coefficient determination.
Practical application of these models to real-world data, especially with experimental noise, requires refinement.

Purpose of the Study:

To practically apply theoretical expressions for solute adsorption kinetics in porous carbon cylindrical granules.
To refine an initial estimated diffusion coefficient by fitting theoretical curves to experimental data.
To quantitatively analyze the effects of surface modification, pH, and temperature on adsorption kinetics and diffusion coefficients.

Main Methods:

Utilized analytical expressions for solute adsorption kinetics based on Fick's Second Law.
Applied a simulation method to refine effective diffusion coefficients from experimental adsorption data.
Analyzed experimental data for activated carbons, considering noise contamination.
Investigated the influence of surface modification, pH, and temperature on adsorption kinetics.

Main Results:

Successfully applied theoretical models to experimental adsorption data for activated carbons.
Demonstrated the utility of a simulation method for determining effective diffusion coefficients in the presence of experimental noise.
Quantified the impact of surface modification, pH, and temperature on adsorption kinetics and diffusion within the porous structure.

Conclusions:

The study provides the first practical application of analytical expressions for solute adsorption kinetics in porous carbon.
Simulation methods are effective for refining diffusion coefficients from noisy experimental data.
Understanding the influence of various factors is crucial for accurate diffusion coefficient determination in activated carbons.