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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

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Related Experiment Video

Updated: Jul 14, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

Technological advances in radioimmunotherapy.

J L J Dearling1, R B Pedley

  • 1Cancer Research UK Targeting & Imaging Group, Department of Oncology, University College London (Hampstead Campus), London, UK. j.dearling@hotmail.com

Clinical Oncology (Royal College of Radiologists (Great Britain))
|June 1, 2007
PubMed
Summary

Radioimmunotherapy (RIT) offers targeted cancer treatment by delivering radioactive isotopes directly to cancer cells, sparing healthy tissues. Recent advancements show promising results for treating difficult-to-reach metastases, improving therapeutic outcomes.

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Last Updated: Jul 14, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
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Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
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Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiotherapy

Background:

  • Metastatic cancers often evade conventional treatments like surgery or external beam radiotherapy.
  • Systemic targeted therapies are crucial for addressing widespread metastatic disease.
  • Radioimmunotherapy (RIT) utilizes targeted delivery of radionuclides to treat cancer.

Purpose of the Study:

  • To review recent technological advancements in Radioimmunotherapy.
  • To summarize encouraging clinical findings from RIT studies.
  • To highlight the potential of RIT in managing metastatic cancers.

Main Methods:

  • Review of recent laboratory technological developments in RIT.
  • Analysis of published clinical study findings on RIT efficacy and safety.
  • Synthesis of current knowledge on targeted radionuclide delivery for cancer.

Main Results:

  • Technological innovations are enhancing the precision and efficacy of RIT.
  • Clinical studies demonstrate increasingly positive outcomes in RIT applications.
  • RIT shows significant promise in treating cancers that have metastasized.

Conclusions:

  • Radioimmunotherapy represents a significant advancement in targeted cancer therapy.
  • Ongoing technological and clinical developments are expanding the role of RIT.
  • RIT offers a viable strategy for improving treatment outcomes in metastatic disease.