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Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
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Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
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Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.

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Related Experiment Video

Updated: Jul 14, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

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Published on: February 22, 2019

The case for maternal vaccination against pertussis.

Frits R Mooi1, Sabine C de Greeff

  • 1Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, Netherlands. fr.mooi@rivm.nl

The Lancet. Infectious Diseases
|June 1, 2007
PubMed
Summary

Maternal pertussis vaccination can protect infants too young to be vaccinated. This strategy may decrease infant illness and death from pertussis, especially with rising disease incidence.

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Area of Science:

  • Immunology
  • Public Health
  • Pediatrics

Background:

  • Pertussis (whooping cough) incidence is rising globally, particularly in unvaccinated infants.
  • Infants too young for vaccination face the highest risk of pertussis complications and death.
  • Existing pertussis vaccines have high coverage but are not preventing widespread outbreaks.

Purpose of the Study:

  • To evaluate maternal vaccination as a strategy to protect infants against pertussis.
  • To assess the safety and efficacy of maternal pertussis immunization.

Main Methods:

  • Review of existing studies on maternal vaccination with whole-cell pertussis vaccines.
  • Analysis of antibody transfer and infant protection data from previous research.
  • Assessment of adverse effects in mothers and infants.

Main Results:

  • Maternal vaccination with whole-cell pertussis vaccines showed no serious adverse effects in mothers or infants.
  • Studies indicated protection of newborn infants following maternal immunization.
  • Evidence suggests antibody transfer from mother to infant confers protection against pertussis.

Conclusions:

  • Maternal pertussis vaccination is a potentially effective method to safeguard newborns.
  • This approach can reduce infant morbidity and mortality from pertussis.
  • Further research supports maternal immunization for infant protection against pertussis.