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Updated: Jul 14, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Remitting seronegative symmetrical synovitis with pitting oedema associated with lung malignancy
Francesco U S Mattace-Raso1, Tischa J M van der Cammen
1Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. f.mattaceraso@erasmusmc.nl
Age and Ageing
|June 1, 2007
Summary
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome, typically seen in men, can occur with lung cancer. Medical professionals should investigate potential malignancies in RS3PE patients, even without typical symptoms.
Area of Science:
- Rheumatology
- Oncology
Background:
- Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a distinct rheumatologic condition.
- It primarily affects elderly males and characteristically shows rapid improvement with low-dose corticosteroids.
Observation:
- This report details a rare case of RS3PE syndrome occurring concurrently with lung malignancy.
- The patient was a 78-year-old woman, presenting a demographic atypical for RS3PE syndrome.
Findings:
- The concurrence of RS3PE syndrome and lung cancer was observed in this patient.
- The case highlights a potential, though uncommon, association between the rheumatologic condition and neoplastic disease.
Implications:
- The findings suggest that underlying malignancies should be considered in the differential diagnosis of RS3PE syndrome.
- Screening for cancer is recommended in patients diagnosed with RS3PE, particularly when classic symptoms like weight loss or fever are absent or equivocal.
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