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Published on: February 10, 2023
Expression of cyclooxygenase-2 in urinary bladder in rats with cyclophosphamide-induced cystitis
Mary Beth Klinger1, Abbey Dattilio, Margaret A Vizzard
1Univ. of Vermont College of Medicine, Dept. of Neurology, D415A Given Research Bldg., Burlington, VT 05405. margaret.vizzard@uvm.edu).
Abstract:
These studies examined the expression of cyclooxygenase-2 (COX-2) expression in the urothelium and suburothelial space and detrusor from rats treated with cyclophosphamide (CYP) to induce acute (4 h), intermediate (48 h), or chronic (10-day) cystitis. Western blot analysis and immunohistochemistry were used to demonstrate COX-2 expression. In whole mount preparations of urinary bladder, nerve fibers in the suburothelial plexus, and inflammatory cell infiltrates were characterized for COX-2 expression after CYP-induced cystitis. COX-2 expression significantly (P
