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Related Experiment Videos

Mamu-B*08-positive macaques control simian immunodeficiency virus replication.

John T Loffredo1, Jess Maxwell, Ying Qi

  • 1Wisconsin National Primate Research Center, University of Wisconsin-Madison, 555 Science Drive, Madison, WI 53711, USA.

Journal of Virology
|June 1, 2007
PubMed
Summary
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The Mamu-B*08 gene variant in rhesus macaques is linked to controlling simian immunodeficiency virus (SIV) replication. This finding offers insights into immune protection and viral containment strategies relevant to human immunodeficiency virus (HIV) elite controllers.

Area of Science:

  • Immunology
  • Virology
  • Genetics

Background:

  • Major histocompatibility complex (MHC) class I alleles influence control of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV).
  • Identifying specific MHC alleles associated with viral control is crucial for understanding immune responses.

Purpose of the Study:

  • To investigate the association of the rhesus macaque MHC class I allele Mamu-B*08 with control of SIV replication.
  • To evaluate Mamu-B*08 as a potential genetic marker for viral containment in SIV-infected macaques.

Main Methods:

  • Design of sequence-specific primers for Mamu-B*08 detection using PCR.
  • Screening of 196 SIV(mac)239-infected Indian rhesus macaques for the Mamu-B*08 allele.
  • Statistical analysis comparing allele frequency between elite controllers and progressors and its effect on viremia.

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Main Results:

  • Mamu-B*08 was significantly overrepresented in SIV elite controllers (38%) compared to progressors (3%).
  • The presence of Mamu-B*08 was associated with a 7.34-fold decrease in chronic phase viremia.
  • A strong statistical association (P = 0.00001) was found between Mamu-B*08 and elite controller status.

Conclusions:

  • The Mamu-B*08 allele plays a significant role in controlling SIV replication in rhesus macaques.
  • Mamu-B*08-positive macaques serve as a valuable model for studying MHC class I-associated immune protection and viral containment.
  • Findings contribute to understanding correlates of immune protection in human HIV elite controllers.