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Leukogenic effect of complex indigo powder.

C X Liu1, W G He

  • 1Tianjin Institute of Pharmaceutical Research, State Pharmaceutical Administration of China.

Journal of Ethnopharmacology
|August 1, 1991
PubMed
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Complex indigo powder increased leukocyte counts in irradiated rats. However, it did not prevent irradiation-induced leukopenia or cause toxicity in mice at tested doses.

Area of Science:

  • Pharmacology
  • Toxicology
  • Hematology

Background:

  • Irradiation can induce significant leukopenia, a decrease in white blood cell count.
  • Complex indigo powder is traditionally used as an anti-scrofula treatment.

Purpose of the Study:

  • To investigate the effects of complex indigo powder on leukocyte counts in irradiated rats.
  • To assess the prophylactic efficacy of complex indigo powder against irradiation-induced leukopenia.
  • To evaluate the general toxicity of complex indigo powder in mice.

Main Methods:

  • Rats were administered complex indigo powder orally at 0.5 g/kg daily post-irradiation.
  • Prophylactic administration of complex indigo powder was tested against irradiation-induced leukopenia.
  • Mice received oral doses of complex indigo powder up to 6 g/kg to assess toxicity.

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Main Results:

  • Oral administration of complex indigo powder (0.5 g/kg/day) increased leukocyte counts in irradiated rats.
  • Prophylactic administration did not prevent irradiation-induced leukopenia.
  • No adverse effects on growth were observed in rats at the tested dosage.
  • Oral doses up to 6 g/kg showed no toxic reactions in mice.

Conclusions:

  • Complex indigo powder demonstrates a potential to modulate leukocyte counts following irradiation injury in rats.
  • It does not offer protective effects against the onset of irradiation-induced leukopenia.
  • The compound exhibits a favorable safety profile at tested therapeutic and higher doses in rodent models.