Related Experiment Video
Updated: Jul 14, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
The difficulties of studying children's pain at home
Debra M Van Kuiken1, Li Lin, Myra Martz Huth
1Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. debra.vankuiken@cchmc.org
Insights
Analyzing children's post-tonsillectomy pain is challenging due to inconsistent pain diary entries. Hierarchical linear modeling (HLM) offers a solution for analyzing this unbalanced data and controlling for analgesic use.
Area of Science:
- Pediatric Pain Management
- Clinical Research Methodology
Background:
- Tonsillectomy surgery in children often results in moderate to severe pain.
- Accurate pain assessment is crucial for effective post-operative care and research.
Purpose of the Study:
- To address challenges in analyzing pediatric pain data from inconsistent post-tonsillectomy diaries.
- To identify appropriate statistical methods for handling unbalanced data and analgesic use in pain research.
Main Methods:
- Data analysis of pain diaries collected 24 hours after ambulatory tonsillectomy.
- Conversion of opioid analgesics to morphine equivalents and non-opioids as separate covariates.
- Application of Hierarchical Linear Modeling (HLM) to analyze unbalanced and incomplete repeated-measures data.
Main Results:
- Inconsistent diary entries and analgesic use complicated group comparisons.
- HLM demonstrated the ability to analyze unbalanced data effectively.
- HLM provided a method to control for analgesic interventions in pain research.
Conclusions:
- Standard pain diary protocols may yield inconsistent data in pediatric post-tonsillectomy studies.
- Hierarchical Linear Modeling (HLM) is a suitable statistical approach for analyzing incomplete and unbalanced pain data in pediatric home-based research.
- Controlling for analgesic use is essential for maintaining the construct validity of pain assessment research in children.
Abstract:
Children experience moderate to severe pain in the days after tonsillectomy surgery. This article describes the challenges of analyzing data from pain diaries 24 hours after ambulatory tonsillectomy surgery. Instructions were to record pain levels every 4 hours and the analgesic as given; however, the number of entries was inconsistent, making comparison of groups difficult. The use of analgesics can threaten the construct validity of cause and must be considered and controlled statistically. Opioids were converted to morphine equivalents and the nonopioids were held as a separate covariate. This article describes the steps taken to find an appropriate statistical means of dealing with inconsistent diary entries and analgesic use. Hierarchical linear modeling (HLM) provides a means to analyze unbalanced data and control for analgesics. Issues of control must be addressed in research that measures children's pain in the home. HLM can address issues of incomplete data in repeated-measures studies.
Related Concept Videos
Analgesia and Pain Management
Pain
