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Related Experiment Videos

Perceived behavioral changes in early multiple sclerosis.

Fabiana Souza Lima1, Samanta Simioni, Laure Bruggimann

  • 1Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Behavioural Neurology
|June 1, 2007
PubMed
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Early multiple sclerosis (MS) patients show behavioral changes similar to other chronic conditions. However, distinct correlations between behavioral symptoms and executive dysfunction may indicate unique MS-related changes, especially with cognitive impairment.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Neurology

Background:

  • Acquired behavioral changes are recognized in advanced multiple sclerosis (MS).
  • The early phase of MS may present subtle behavioral modifications.
  • Distinguishing MS-specific behavioral changes from other chronic inflammatory disorders is crucial.

Purpose of the Study:

  • To identify behavioral modifications specific to the early pathological process of MS.
  • To compare behavioral changes in early MS patients with those in controls with non-central nervous system (CNS) inflammatory disorders.
  • To explore the relationship between perceived behavioral changes and executive dysfunction in early MS.

Main Methods:

  • Eighty-eight early MS patients (EDSS score ≤ 2.5) and 48 controls were assessed.

Related Experiment Videos

  • The Iowa Scale of Personality Change (ISPC) evaluated perceived behavioral changes by informants.
  • The Dysexecutive Questionnaire (DEX) screened for executive behavioral disturbances.

    • Main Results:

    • Perceived behavioral changes (PBCs) and executive dysfunction scores were similar between early MS and control groups.
    • Commonly reported PBCs included lack of stamina, mood lability, anxiety, stress vulnerability, and irritability.
    • Correlations between PBCs and DEX scores differed between groups, and MS patients with cognitive impairment showed more PBCs and higher DEX scores.

    Conclusions:

    • Early MS patients exhibit behavioral changes comparable to other chronic non-CNS disorders.
    • Qualitative differences in the relationship between behavioral symptoms and executive changes may exist in MS.
    • Behavioral symptoms in early MS appear associated with cognitive deficits, warranting longitudinal study.