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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

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Related Experiment Video

Updated: Jul 14, 2026

Measuring Biophysical and Psychological Stress Levels Following Visitation to Three Locations with Differing Levels of Nature
05:33

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Published on: June 19, 2019

Sustained leukocyte count during rising cortisol level.

Varda Deutsch1, Liat Lerner-Geva, Adi Reches

  • 1Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Hashomer, Israel.

Acta Haematologica
|June 1, 2007
PubMed
Summary

Elevated cortisol levels correlate with increased white blood cell counts in hospitalized patients. Normal cortisol levels are associated with a significant drop in white blood cell counts over one week.

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Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
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Measuring Biophysical and Psychological Stress Levels Following Visitation to Three Locations with Differing Levels of Nature
05:33

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Published on: June 19, 2019

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

Area of Science:

  • Endocrinology
  • Hematology
  • Clinical Medicine

Background:

  • Leukocyte counts are critical indicators of immune status.
  • Serum cortisol levels fluctuate in hospitalized patients.
  • The relationship between cortisol and leukocyte dynamics requires further elucidation.

Purpose of the Study:

  • To investigate the trend of leukocyte counts in relation to serum cortisol levels.
  • To determine if cortisol influences white blood cell count maintenance in hospitalized individuals.

Main Methods:

  • Retrospective chart review of 59 hospitalized patients.
  • Analysis of sequential blood profiles over a 2-week period.
  • Subgroup analysis based on normal (< 25 microg/dl) versus elevated (>= 25 microg/dl) cortisol levels.

Main Results:

  • Baseline white blood cell counts (WBCCs) were comparable between normal and elevated cortisol groups.
  • After one week, WBCCs significantly decreased with normal cortisol but increased with elevated cortisol (p = 0.002).
  • A significant positive correlation (r = 0.33) was found between cortisol levels and concomitant WBCCs at 1 week; platelet counts showed no such pattern.

Conclusions:

  • Cortisol appears to positively influence the maintenance of elevated leukocyte counts.
  • This suggests a potential endocrine mechanism regulating leukocyte levels in clinical settings.