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[Waldenström's macroglobulinemia, cryoglobulinemia type I and membranous glomerulonephritis]
M I González Anglada1, J González García, A del Arco
1Departamento de Medicina Interna, Hospital La Paz, Madrid.
Abstract:
Renal complications in Waldenström's macroglobulinemia (WM) are infrequent and are characterized by the presence of PAS positive amorphous hyaline deposits in the capillary lumen, infiltrated with lymphoplasmatic cells with PAS positive inclusions in the interstices and intratubular hyaline cylinders. Membranous glomerulonephritis may be a paraneoplastic manifestation of the lymphoproliferative processes. A 67-year-old male was diagnosed of WM, type-I cryoglobulinemia with renal insufficiency without proteinuria. Renal histological examination revealed changes characteristic of nephropathy associated to WM as well as membranous glomerulonephritis. This association has not been described previously. The coexistence of two pathogenic mechanisms with a common base, lymphoproliferative disease, may explain this association.
Insights
Renal complications in Waldenström's macroglobulinemia (WM) are rare. This study describes a novel association between WM-related nephropathy and membranous glomerulonephritis in a single patient.
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Renal complications in Waldenström's macroglobulinemia (WM) are uncommon.
- Typical WM nephropathy involves PAS-positive deposits and lymphoplasmatic cell infiltration.
Observation:
- A 67-year-old male with WM, type-I cryoglobulinemia, and renal insufficiency without proteinuria was studied.
- Renal histology revealed both WM nephropathy and membranous glomerulonephritis.
Findings:
- This is the first reported case associating WM-related nephropathy with membranous glomerulonephritis.
- The patient presented with renal insufficiency but no proteinuria.
Implications:
- The coexistence of two distinct renal pathologies suggests a shared lymphoproliferative origin.
- This finding expands the understanding of renal manifestations in Waldenström's macroglobulinemia.