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Updated: Jul 14, 2026

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Published on: August 15, 2025
The pterygopalatine fossa: an anatomic report.
Fabio Roberti1, Nicola Boari, Pietro Mortini
1Department of Neurological Surgery, George Washington University, Washington, DC 20037, USA. roberti.fabio@gmail.com
The pterygopalatine fossa (PPF) is a key area in cranial surgery. Understanding its complex neurovascular anatomy is vital for preventing surgical complications and disease spread.
Area of Science:
- Anatomy
- Neurosurgery
- Surgical Anatomy
Background:
- The pterygopalatine fossa (PPF) is a critical anatomical space in the skull base.
- Its numerous openings facilitate the spread of infections and malignancies.
- Understanding PPF neurovascular anatomy is essential for cranial base surgery.
Purpose of the Study:
- To provide a detailed anatomical report of the pterygopalatine fossa.
- To describe the neurovascular content and vascular patterns within the PPF.
- To emphasize the importance of anatomical knowledge for surgical safety.
Main Methods:
- Dissection of twelve sides of six fixed cadaveric heads.
- Utilized a LeFort I maxillary osteotomy approach.
- Transantral exposure for visualizing neurovascular structures of the PPF.
Main Results:
- Detailed observation of the pterygopalatine fossa's deep anatomical location.
- Characterization of the rich neurovascular content within the fossa.
- Identified variable vascular morphology in the third portion of the maxillary artery within the PPF.
Conclusions:
- Comprehensive knowledge of the pterygopalatine fossa's anatomy is crucial.
- Understanding the relationships and functions of neurovascular structures minimizes surgical risks.
- Accurate anatomical insight is key to reducing postsurgical morbidity and intraoperative complications.
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