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Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling
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Protein interactions from complexes: a structural perspective

Luke Hakes1, David L Robertson, Stephen G Oliver

  • 1Centre for the Analysis of Biological Complexity, Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.

Comparative and Functional Genomics
|June 1, 2007
PubMed

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Protein-Protein Interfaces02:04

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Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Protein Complex Assembly02:41

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Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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