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06:47
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Mean platelet volume: association with adverse neonatal outcome
S Gioia1, J Piazze, M M Anceschi
1Institute of Gynecology, Perinatology and Child Health, University La Sapienza, Rome, Italy.
Platelets
|June 1, 2007
Summary
Maternal mean platelet volume (MPV) is higher in pregnancies with abnormal Doppler velocimetry. An MPV of 10 fl or greater may indicate severe fetal oxygen issues at birth.
Area of Science:
- Obstetrics and Gynecology
- Fetal Medicine
- Hematology
Background:
- Altered maternal-fetal Doppler velocimetry is associated with pregnancy complications like pre-eclampsia and intrauterine growth retardation.
- Mean platelet volume (MPV) is a marker of platelet activation and function.
- Investigating MPV in pregnancies with abnormal Doppler velocimetry may offer insights into fetal well-being.
Purpose of the Study:
- To explore the association between maternal MPV and oxygen-metabolic changes in pregnancies with abnormal maternal-fetal Doppler velocimetry.
- To determine if MPV can predict adverse neonatal outcomes in fetuses with compromised Doppler velocimetry.
- To establish a potential MPV cutoff for identifying fetuses at risk for severe oxygen support needs or low umbilical artery pH.
Main Methods:
- A case-control study comparing pregnant women with abnormal Doppler velocimetry (n=57) to a control group with normal Doppler velocimetry (n=145).
- Maternal venous blood was collected for MPV measurement shortly after Doppler velocimetry.
- Receiver Operating Characteristic (ROC) curve analysis was used to identify MPV cutoff values for predicting adverse neonatal outcomes.
Main Results:
- MPV was significantly higher in women with abnormal Doppler velocimetry compared to the control group (9.1 fl vs. 8.0 fl).
- An MPV cutoff of ≥ 10 fl was significantly associated with adverse outcomes, including prolonged neonatal oxygen support or low umbilical artery pH (sensitivity: 45%, specificity: 89.7%).
- This suggests a link between elevated MPV and increased fetal compromise in pregnancies with Doppler alterations.
Conclusions:
- Elevated maternal MPV is observed in pregnancies with abnormal Doppler velocimetry.
- A maternal MPV of 10 fl or higher may serve as a predictive marker for severe neonatal oxygenation issues and metabolic acidosis at birth in fetuses with Doppler velocimetry alterations.
- MPV could be a valuable, non-invasive biomarker for assessing fetal risk in complicated pregnancies.
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