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Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency
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Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Published on: August 6, 2014

Alteractions of germ cells leading to mutagenesis and their detection

D J Brusick

    Environmental Health Perspectives
    |June 1, 1978
    PubMed

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    Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
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