Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin: potential functions in the oral cavity.

Antonio Cutando1, Gerardo Gómez-Moreno, Carlos Arana

  • 1Department of Special Care in Dentistry, School of Dentistry, University of Granada, Granada, Spain. acutando@ugr.es

Journal of Periodontology
|June 2, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-fidelity simulation in airway management training: results from the AIR-MASTER-SIM randomised study.

Frontiers in medicine·2026
Same author

The gut microbiota directs vitamin A flux to regulate intestinal T cell development.

Cell host & microbe·2026
Same author

Crossing life-saving thresholds: learning-forgetting trajectories in secondary-school basic life-support training: project threshold-beat.

Frontiers in public health·2026
Same author

Medium-term retention and household diffusion of basic life support skills after a school-wide educational intervention: PLANIFICARCP PROJECT.

Resuscitation plus·2026
Same author

Melatonin Overcomes Cancer Multidrug Resistance by Downregulating ABCB1 Expression and Modulating Mitochondrial Function.

Journal of pineal research·2025
Same author

Genetic haplotypes in <i>VWA8, OSBPL6,</i> and <i>ADAMTS9-AS2</i> are associated with immune-related adverse effects in ICI-treated patients with cancer.

Journal for immunotherapy of cancer·2025

Melatonin, a hormone regulating circadian rhythms, may protect oral tissues from oxidative stress and aid in alveolar bone regeneration. Salivary melatonin levels may increase in response to periodontal inflammation.

Area of Science:

  • Endocrinology
  • Oral Biology
  • Biochemistry

Background:

  • Melatonin is synthesized by the pineal gland and influences circadian rhythms.
  • It possesses antioxidant, immunomodulatory, and bone-formation-promoting properties.
  • Melatonin secretion patterns convey light-dark cycle information, organizing biological rhythms.

Purpose of the Study:

  • To explore the role of melatonin in oral health, particularly in periodontal disease.
  • To investigate melatonin's potential protective effects against oxidative stress in the oral cavity.
  • To assess melatonin's contribution to alveolar bone regeneration.

Main Methods:

  • An extensive literature review was conducted using major scientific databases (PubMed, Science Direct, Web of Knowledge).

Related Experiment Videos

Main Results:

  • Melatonin, present in saliva, may be relevant for dental disorders like periodontal disease.
  • Periodontal inflammation can lead to increased blood and salivary melatonin levels.
  • Free radicals and altered immune responses exacerbate periodontal diseases.

Conclusions:

  • Melatonin may protect the oral cavity from oxidative stress-induced tissue damage.
  • It may promote alveolar bone regeneration by stimulating collagen synthesis and modulating bone cell activity.
  • Salivary melatonin's role in periodontal health warrants further investigation.