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Transdermal oxybutynin: a review.

Greg L Shaw1, Hiten Rh Patel

  • 1University College Hospital, Institute of Urology, Euston Road, London, UK.

Expert Opinion on Drug Metabolism & Toxicology
|June 2, 2007
PubMed
Summary
This summary is machine-generated.

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Transdermal oxybutynin offers effective overactive bladder treatment with fewer side effects than oral options. This method is ideal for patients intolerant to oral anticholinergics or unable to take them.

Area of Science:

  • Pharmacology
  • Urology

Background:

  • Overactive bladder (OAB) is a prevalent condition significantly impacting quality of life.
  • Oral anticholinergic drugs are the primary pharmacological treatment for OAB.
  • Common side effects like dry mouth and constipation limit patient adherence to oral therapies.

Purpose of the Study:

  • To review the pharmacokinetics, pharmacodynamics, efficacy, and safety of transdermal oxybutynin.
  • To evaluate transdermal oxybutynin as an alternative treatment for overactive bladder.

Main Methods:

  • Review of existing literature on transdermal oxybutynin.
  • Analysis of pharmacokinetic and pharmacodynamic data.
  • Assessment of clinical trial results regarding efficacy and safety.

Related Experiment Videos

Main Results:

  • Transdermal oxybutynin demonstrates comparable efficacy to oral treatment for overactive bladder.
  • Minimizes systemic anticholinergic side effects compared to oral administration.
  • Frequent skin reactions necessitate rotation of application sites.

Conclusions:

  • Transdermal oxybutynin is a valuable therapeutic option for managing overactive bladder.
  • Particularly beneficial for patients experiencing intolerable side effects from oral medications.
  • Also suitable for individuals for whom oral drug administration is not feasible.