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Related Concept Videos

Classification and Mechanical Properties of Synthetic Polymers01:28

Classification and Mechanical Properties of Synthetic Polymers

Synthetic polymers are classified as elastomers, fibers, or plastics based on their crystallinity. Crystallinity, the degree of long-range order in the solid state, influences the mechanical properties (stretching or contracting) of elastomers. Elastomers are flexible polymers that can expand or contract easily upon the application of an external force. They have numerous crosslinks that pull them back into their original shape when stress is removed. Silicones, for instance, are highly elastic...
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
Characteristics and Nomenclature of Copolymers01:24

Characteristics and Nomenclature of Copolymers

Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
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Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...

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Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
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Synthesis and characterization of functional elastomeric poly(ester amide) co-polymers.

G Jokhadze1, M Machaidze, H Panosyan

  • 1Research Centre for Medical Polymers and Biomaterials, Georgian Technical University, P.O. Box 24, Tbilisi 0179, Georgia, USA.

Journal of Biomaterials Science. Polymer Edition
|June 2, 2007
PubMed
Summary

New biodegradable polymers, co-poly(ester amides) (co-PEAs), were synthesized with functional carboxylic acid groups. These polymers showed significant enzymatic degradation and were used to attach iminoxyl radicals for further study.

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Organic Synthesis

Background:

  • Developing novel biodegradable polymers is crucial for sustainable materials.
  • Functional polymers with pendant groups offer versatile applications in drug delivery and diagnostics.
  • Enzymatic degradation studies are essential for evaluating biocompatibility and environmental impact.

Purpose of the Study:

  • To synthesize a new family of random co-poly(ester amides) (co-PEAs) with reactive pendant carboxylic acid groups.
  • To investigate the in vitro enzymatic biodegradation of these novel co-PEAs.
  • To explore the covalent attachment of iminoxyl radicals (4-amino-TEMPO) to the co-PEA-based polyacids and study their release kinetics.

Main Methods:

  • Co-polycondensation of amino acid diesters and dicarboxylic acid diesters.
  • Catalytic hydrogenolysis to convert benzyl ester groups to carboxylic acid groups.
  • Characterization using standard methods and in vitro biodegradation assays with alpha-chymotrypsin and lipase.
  • Covalent attachment of 4-amino-TEMPO and analysis of release kinetics.

Main Results:

  • Successfully synthesized random co-poly(ester amides) (co-PEAs) with pendant carboxylic acid groups.
  • Demonstrated significant in vitro enzymatic-catalyzed biodegradation of co-PEAs in the presence of hydrolases.
  • Achieved covalent attachment of iminoxyl radicals to co-PEA-based polyacids, with studies on release kinetics.

Conclusions:

  • The synthesized co-PEAs are biodegradable and possess functional groups for further modification.
  • These polymers show promise for applications requiring controlled release of attached molecules.
  • Further research can explore the potential of these functionalized polymers in biomedical fields.