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Related Experiment Video

Updated: May 8, 2026

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

After hours keeps clock researchers CRYing Overtime.

David M Virshup¹, Daniel B Forger

¹Department of Pediatrics and the Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. david.virshup@hci.utah.edu

|June 2, 2007

Summary

The circadian regulator CRY is degraded by the F-box E3 ubiquitin ligase FBXL3. This confirms targeted protein degradation is crucial for the mammalian circadian clock mechanism.

Area of Science:

Biochemistry
Molecular Biology
Chronobiology

Background:

The mammalian circadian clock regulates daily biological rhythms.
Circadian regulators require precise control mechanisms for proper function.

Purpose of the Study:

To investigate the degradation pathway of the circadian regulator CRY.
To identify the E3 ubiquitin ligase responsible for CRY targeting.

Main Methods:

Utilized molecular biology techniques to study protein degradation.
Investigated the interaction between CRY and E3 ubiquitin ligases.

Main Results:

Identified FBXL3 as the F-box E3 ubiquitin ligase that targets CRY for degradation.
Confirmed the role of targeted protein degradation in the circadian clock.

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Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

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Last Updated: May 8, 2026

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

Conclusions:

FBXL3-mediated degradation of CRY is a key regulatory step in the mammalian circadian clock.
Targeted protein degradation is essential for the functional integrity of the circadian clock.