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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
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Quantifying Mixing using Magnetic Resonance Imaging
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Magnetic resonance microscopic imaging based on high-order intermolecular multiple-quantum coherences.

Jee-Hyun Cho1, Sangdoo Ahn, Chulhyun Lee

  • 1Magnetic Resonance Imaging Team, Korea Basic Science Institute, Ochang, Cheongwon, Chungbuk 363-883, Korea.

Magnetic Resonance Imaging
|June 2, 2007
PubMed
Summary

High-order intermolecular multiple-quantum coherences (iMQCs) enable advanced magnetic resonance microscopy. These iMQCs provide unique imaging contrast based on sample microstructure and coherence order, observable even at high magnetic fields.

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Area of Science:

  • Magnetic Resonance Imaging
  • Quantum Coherence Phenomena
  • Microscopy Techniques

Background:

  • Traditional intermolecular multiple-quantum coherences (iMQCs) primarily utilize zero and double quantum coherences for imaging.
  • High-order iMQCs have been less explored in magnetic resonance microscopy.
  • Advancements in magnetic field strengths offer new possibilities for sensitive imaging techniques.

Purpose of the Study:

  • To evaluate the feasibility of using high-order intermolecular multiple-quantum coherences (iMQCs) for magnetic resonance microscopy.
  • To investigate the potential of high-order iMQCs to provide unique imaging contrast.
  • To assess the observability of high-order iMQC signals at high magnetic fields (7 and 14 T).

Main Methods:

  • Experimental studies were conducted using model systems.
  • Magnetic resonance microscopy was employed at high field strengths (7 T and 14 T).
  • High-order intermolecular multiple-quantum coherences (iMQCs) were generated and detected.

Main Results:

  • High-order iMQC microscopic images were readily observable at high magnetic fields.
  • The observed images exhibited unique contrast characteristics.
  • Image contrast was found to be dependent on both the sample's microstructure and the specific coherence order used.

Conclusions:

  • High-order iMQCs are feasible for advanced magnetic resonance microscopy.
  • This technique offers unique contrast mechanisms valuable for characterizing microstructures.
  • High-field strengths facilitate the observation and application of high-order iMQCs in imaging.