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Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
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Published on: July 12, 2012

Manganese-enhanced auditory tract-tracing MRI with cochlear injection.

Jae-Won Lee1, Ji-Ae Park, Jae-Jun Lee

  • 1Department of Biomedical Engineering, Kyungpook National University, Daegu 700-412, Republic of Korea.

Magnetic Resonance Imaging
|June 2, 2007
PubMed
Summary

Manganese ion (Mn2+) enables repeated in vivo neuronal tracing of the auditory pathway in guinea pigs. This MRI-compatible method visualizes neural circuitry, offering new insights into auditory physiology and axonal transport.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Auditory System Research

Background:

  • Histological methods for neuronal tracing are invasive and not repeatable.
  • Manganese ion (Mn2+) is increasingly used as an in vivo neuronal tract tracer.
  • Mn2+ enters cells via voltage-gated calcium channels and acts as an MRI contrast agent.

Purpose of the Study:

  • To describe the neuroaxonal tracing of the auditory pathway in living guinea pigs using Mn2+.
  • To evaluate Mn2+ as a tool for visualizing auditory neural circuitry in vivo.
  • To explore the potential for repeated imaging of neural pathways.

Main Methods:

  • Small, focal injections of Mn2+ into the cochlea of living guinea pigs.
  • Utilizing Mn2+ as a paramagnetic MRI contrast agent.
  • Monitoring contrast enhancement along known auditory pathway circuitry.

Main Results:

  • Significant contrast enhancement was observed along the established neuronal circuitry of the auditory pathway.
  • Mn2+ successfully traced neuroaxonal pathways following cochlear injection.
  • The method allowed for visualization of neural connections in vivo.

Conclusions:

  • Mn2+ serves as an effective in vivo neuronal tract tracer for the auditory system.
  • This non-invasive, repeatable MRI approach provides new insights into auditory physiology.
  • The technique is valuable for studying axonal transport and neuronal activity in the central auditory system.