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A model of globin evolution.

Serge N Vinogradov1, David Hoogewijs, Xavier Bailly

  • 1Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA. svinogra@med.wayne.edu

Gene
|June 2, 2007
PubMed
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This study reveals the evolutionary origins of bacterial globins, proposing they evolved in Bacteria before transferring to Archaea and Eukaryotes. Flavohemoglobins are identified as the likely ancestral globin type.

Area of Science:

  • * Molecular Evolution
  • * Bioinformatics
  • * Genomics

Background:

  • * Globins are heme-containing proteins found across all domains of life.
  • * Previous studies have identified globins in bacteria, archaea, and eukaryotes, but their evolutionary relationships remain unclear.
  • * Single-domain sensor globins were unexpectedly found in Bacteria, Fungi, and Euryarchaeota.

Purpose of the Study:

  • * To investigate the evolutionary history and origins of globin families.
  • * To propose a model for globin evolution, including the ancestral globin type and diversification pathways.
  • * To explore the role of lateral gene transfer in globin distribution across different kingdoms.

Main Methods:

  • * Bioinformatic analysis of globin sequences from 426 bacterial, 32 archaeal, and 67 eukaryote genomes.

Related Experiment Videos

  • * Bayesian phylogenetic tree construction to infer evolutionary relationships.
  • * Iterated Position-Specific Iterated BLAST (PSI-BLAST) searches to determine sequence homology and evolutionary proximity.

    • Main Results:

    • * Globins are present in diverse bacterial, archaeal, and eukaryotic lineages.
    • * Bacterial flavohemoglobins show closer evolutionary ties to metazoan globins than to other bacterial globin types (2-over-2 globins and globin-coupled sensors).
    • * The presence of single-domain sensor globins in Fungi and Euryarchaeota is likely due to lateral gene transfer from Bacteria.

    Conclusions:

    • * Bacteria harbor all major globin subgroups, supporting the hypothesis that globins originated and diversified within this kingdom.
    • * A proposed evolutionary model suggests an ancestral flavohemoglobin-like protein, followed by diversification into sensor and 2-over-2 globins, and subsequent domain additions.
    • * Lateral gene transfer played a significant role in the dissemination of globin lineages to Archaea and Eukaryotes.