Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predicting functional gains in a stroke trial.

Steven C Cramer1, Todd B Parrish, Robert M Levy

  • 1Department of Anatomy, University of California, Irvine, CA, USA. scramer@uci.edu

Stroke
|June 2, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is Pocket Pain Still a Major Issue in Spinal Cord Stimulation?

Neuromodulation : journal of the International Neuromodulation Society·2026
Same author

Autologous adipose-derived mesenchymal stromal cells for chronic traumatic brain injury.

Brain : a journal of neurology·2026
Same author

Opicapone in Parkinson's patients with motor fluctuations: clinical assessments and patient-reported outcomes from the OPTI-ON study.

Clinical parkinsonism & related disorders·2026
Same author

Cognitive reappraisal of food and emotion cues involves common and unique neural contributions.

bioRxiv : the preprint server for biology·2026
Same author

A clinimetric evaluation of the problem behaviors assessment short form (PBA-s) within the context of the Huntington's disease integrated staging system (HD-ISS).

Journal of Huntington's disease·2026
Same author

Multiple System Atrophy Combined Outcome Assessment (MuSyCA): process, format, and validation plan.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same journal

Management of Patients at Risk of Ischemic Stroke With Left Ventricular Systolic Dysfunction in the Absence of Intracardiac Thrombus: A Scientific Statement From the American Heart Association.

Stroke·2026
Same journal

Update on Rehabilitation After Stroke: Global Changes and the Continued Importance of Therapy Intensity, Dose, and Timing.

Stroke·2026
Same journal

ENTF Neuromodulation Yields Reduced Disability After Stroke: An Individual Participant-Level Data Meta-Analysis.

Stroke·2026
Same journal

Menopause and Its Implications for Stroke in Women.

Stroke·2026
Same journal

Physician Approaches to Determining Goals of Stroke Care for Patients Living With Disability or Dementia: Results from the SEED Mixed-Methods Study.

Stroke·2026
Same journal

Aspirin for Stroke Primary Prevention: A Step Toward Genetic-Driven Personalized Medicine.

Stroke·2026
See all related articles

Lower motor cortex activity at baseline predicts greater behavioral gains after stroke rehabilitation. This brain function measure may improve treatment decisions for central nervous system injury recovery.

Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Medical Imaging

Background:

  • Therapies for central nervous system injury focus on enhancing surviving neural elements.
  • Predicting treatment response is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To test if baseline brain function improves prediction of behavioral gains after therapy.
  • To determine if functional magnetic resonance imaging (fMRI) measures enhance outcome prediction.

Main Methods:

  • 24 chronic stroke patients underwent baseline clinical and fMRI assessments.
  • Patients received 6 weeks of rehabilitation therapy with or without motor cortex stimulation.
  • Baseline measures were evaluated for prediction of subsequent trial-related gains.

Related Experiment Videos

Main Results:

  • Greater functional gains were predicted by smaller infarct volume, better baseline clinical status, and lower motor cortex activation on fMRI.
  • Multivariate analysis revealed lower motor cortex activation and better clinical status as significant predictors.
  • Lower baseline motor cortex activation correlated with increased activation post-treatment.

Conclusions:

  • Reduced motor cortex activity at baseline predicts greater behavioral improvement after therapy.
  • Increased cortical activity post-therapy suggests underuse of neural resources in some patients.
  • Baseline brain function measures may aid clinical decision-making for restorative interventions.