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Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study

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Published on: March 8, 2024

Lanostane-type triterpenoids from Diospyros discolor.

Chiy-Rong Chen¹, Chao-Wen Cheng, Min-Hsiung Pan

¹Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.

Chemical & Pharmaceutical Bulletin

|June 2, 2007

Summary

This study isolated four novel lanostane-type triterpenes and three known triterpenes from Diospyros discolor twigs. These compounds were identified using advanced spectroscopic methods for structural elucidation.

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Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study

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Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

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Published on: March 9, 2021

Area of Science:

Natural Product Chemistry
Phytochemistry
Organic Chemistry

Background:

Diospyros discolor is a plant species known for its potential bioactive compounds.
Triterpenes are a class of organic compounds with diverse biological activities.
Lanostane-type triterpenes are a specific subclass with unique structural features.

Purpose of the Study:

To isolate and characterize new lanostane-type triterpenes from Diospyros discolor.
To identify known triterpenes co-occurring in the plant extract.
To elucidate the structures of novel compounds using spectroscopic techniques.

Main Methods:

Methanol extraction of Diospyros discolor twigs.
Isolation of compounds using chromatographic techniques.
Structure elucidation of new compounds via spectroscopic methods (NMR, MS).

Main Results:

Four new lanostane-type triterpenes were successfully isolated and identified.
Three known triterpenes (betulinaldehyde, betulinic acid methyl ester, ursaldehyde) were also identified.
The structures of the novel compounds were fully characterized through comprehensive spectroscopic analysis.

Conclusions:

The methanol extract of Diospyros discolor twigs is a rich source of diverse lanostane-type triterpenes.
This research expands the knowledge of chemical constituents present in Diospyros discolor.
The identified compounds may serve as leads for further pharmacological investigations.