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Impact of viral hepatitis on apo- and lipoprotein status in blood

M Irshad1, R Dube, Y K Joshi

  • 1Clinical Biochemistry Division, Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India. drirshad54@yahoo.com

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|June 2, 2007
PubMed

Insights

Viral hepatitis impacts lipid and lipoprotein profiles, with significant reductions in high-density lipoprotein and specific apolipoprotein changes observed across different liver disease forms. No direct link was found between specific viruses and these lipid alterations.

Area of Science:

  • Hepatology
  • Clinical Biochemistry
  • Virology

Background:

  • Viral hepatitis encompasses a spectrum of liver diseases caused by various viruses.
  • Lipid and apolipoprotein profiles are crucial indicators of metabolic health and disease.
  • Understanding these profiles in viral hepatitis is essential for patient management.

Purpose of the Study:

  • To investigate the effect of viral hepatitis on serum levels of lipoproteins and apolipoproteins.
  • To analyze these effects across different forms of liver disease: acute viral hepatitis, chronic active hepatitis (CAH), cirrhosis, and fulminant hepatic failure.

Main Methods:

  • A study involving 130 adult patients with liver disease and 100 healthy controls.
  • Patients were categorized into four groups based on their liver condition.
  • Serum lipid and apolipoprotein levels were analyzed using various biochemical assays.

Main Results:

  • High-density lipoprotein (HDL) levels were significantly reduced in most viral hepatitis groups, except cirrhosis.
  • Apolipoprotein A (Apo-A) was reduced in acute viral hepatitis and fulminant hepatic failure.
  • Apolipoprotein B (Apo-B) was decreased in CAH and cirrhosis groups; lipoprotein (a) was low across groups compared to controls.

Conclusions:

  • Viral hepatitis affects lipid and apolipoprotein profiles, with distinct patterns observed in different liver disease severities.
  • No clear correlation was established between the specific etiological viruses (Hepatitis B, C, E) and the observed changes in lipid/lipoprotein profiles.
Abstract

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