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Updated: Jul 14, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Tetrasomy 15q11-q13 diagnosed by FISH in a patient with autistic disorder
Karim Ouldim1, Abdelhafid Natiq, Philippe Jonveaux
1Département de génétique médicale, Institut National d'Hygiène, Rabat 11400, Morocco.
Abstract:
We report the case of a Moroccan boy with mental retardation, hyperactivity, epilepsy, developmental problems and behavioural disorders. Cytogenetic analysis showed the presence of a supernumerary marker chromosome. Molecular cytogenetics allowed us to determine the marker as an inverted duplication of chromosome 15. It is the first case of a Moroccan patient with tetrasomy 15q in which fluorescence in situ hybridization (FISH) enabled us to specify the diagnosis. Interestingly, this patient has an infantile autism with cytogenetic abnormalities on chromosomal region 15q11-q13 as reported in patients with Autistic Disorder.
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