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Updated: Jul 14, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
[Gene-environment interactions in the pathogenesis and prevention of type 2 diabetes mellitus]
A Fritsche1, C Thamer, N Stefan
1Abt. Innere Medizin IV, Universitätsklinikum Tübingen. andreas.fritsche@med.uni-tuebingen.de
Abstract:
Type 2 diabetes mellitus is a chronic progressive disease characterized by impaired insulin secretion of the beta cell and impaired insulin sensitivity of different tissues. The incidence of type 2 diabetes mellitus is increasing worldwide, and the disease has reached epidemic proportions. Lifestyle intervention programs are able to delay or possibly prevent the manifestation of type 2 diabetes mellitus. This review summarizes the genetic and environmental factors which influence the risk for type 2 diabetes and their interactions, and determine the success of prevention programs.
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