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Idiopathic hypercalciuria associated with urinary tract infection in children

Vesna D Stojanović1, Biljana O Milosević, Milesa B Djapić

  • 1Department of Pediatric Nephrology, Institute of Child and Youth Health Care, Novi Sad, Serbia. vesnasto@eunet.yu

Pediatric Nephrology (Berlin, Germany)
|June 2, 2007
PubMed

Insights

Idiopathic hypercalciuria (IH) is linked to urinary tract infections (UTI) in children, particularly recurrent cases. Early detection of IH may help manage and prevent childhood UTIs.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Infectious Diseases

Background:

  • Idiopathic hypercalciuria (IH) is a common metabolic abnormality in children.
  • Urinary tract infections (UTI) are prevalent in pediatric populations.
  • The relationship between IH and UTI, especially recurrent UTI, requires further investigation.

Purpose of the Study:

  • To investigate the association between idiopathic hypercalciuria and urinary tract infection in children.
  • To determine if IH is a risk factor for recurrent UTIs in pediatric patients.
  • To identify clinical and laboratory predictors of IH in children with UTI.

Main Methods:

  • Prospective clinical study including 75 children with UTI and 30 healthy controls.
  • Assessment for idiopathic hypercalciuria in all participants.
  • Analysis of UTI recurrence, symptoms (dysuria), and microscopic hematuria.
  • Multifactorial logistic regression for predictive analysis.

Main Results:

  • 21% of children with UTI had IH compared to 7% in controls (p < 0.05).
  • 44% of children with recurrent UTI had IH versus 10% with first-time UTI (p < 0.05).
  • Clinical factors predicted IH diagnosis with 80% accuracy.

Conclusions:

  • Idiopathic hypercalciuria is a significant contributing factor to UTI in children.
  • IH is particularly associated with recurrent urinary tract infections in pediatric patients.
  • Predictive parameters for IH can aid in early diagnosis and management of UTI.

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