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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
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Adrenergic Agonists: Therapeutic Uses

Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
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Characteristics and Outcomes of Cases of Children and Adolescents With Pediatric Inflammatory Multisystem Syndrome in a Tertiary Care Center in Mexico City.

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Related Experiment Video

Updated: Jul 14, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

[Anaphylaxis and anaphylactic shock].

M J E Mendoza Magaña1, M A Vargas Rosasm, J E Guillén Escalón

  • 1Hospital Infantil de México Federico Gómez.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|June 5, 2007
PubMed
Summary

Anaphylaxis, an immediate allergic reaction, affects 3.2-7.6 per 100,000 people yearly, with food triggers common. Early recognition and adrenaline treatment are key for managing this severe hypersensitivity.

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Last Updated: Jul 14, 2026

Measuring Local Anaphylaxis in Mice
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Published on: October 14, 2014

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
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Published on: September 14, 2018

Area of Science:

  • Immunology
  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Anaphylaxis is a severe, immediate hypersensitivity reaction.
  • It involves IgE-mediated mechanisms and can affect multiple body systems.
  • Prevalence ranges from 3.2 to 7.6 cases per 100,000 individuals annually.

Purpose of the Study:

  • To define anaphylaxis and its epidemiological characteristics.
  • To identify key risk factors associated with anaphylaxis.
  • To emphasize the importance of prompt diagnosis and treatment.

Main Methods:

  • Literature review on anaphylaxis prevalence and risk factors.
  • Analysis of clinical presentation and biphasic reactions.
  • Focus on diagnostic criteria and therapeutic interventions.

Main Results:

  • Food ingestion is a significant cause, accounting for 30-50% of cases.
  • Asthma, food allergy, and prior reactions are major risk factors.
  • Biphasic reactions involve symptom recurrence after initial improvement.

Conclusions:

  • Early identification of anaphylaxis signs and symptoms is crucial.
  • Adrenaline administration is the cornerstone of effective anaphylaxis treatment.
  • Understanding risk factors aids in prevention and management strategies.