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A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

Published on: July 5, 2017

[Allergic conjunctivitis in children]

Benjamín Zepeda Ortega1, Miguel Angel Rosas Vargas, Fernando Mitsutoshi Ito Tsuchiya

  • 1Hospital Infantil de México Federico Gómez.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|June 5, 2007
PubMed

Insights

Allergic conjunctivitis, common in children, involves ocular surface inflammation due to type 1 hypersensitivity. This review details its symptoms, classification, pathophysiology, and treatments for allergic eye disease.

Area of Science:

  • Ophthalmology
  • Allergology
  • Immunology

Context:

  • Allergic conjunctivitis encompasses diverse ocular surface diseases, frequently occurring in childhood.
  • It is intrinsically linked to type 1 hypersensitivity reactions and other allergic conditions.
  • The condition presents with acute (seasonal, perennial) and chronic (vernal, atopic, giant papillary) forms.

Purpose:

  • To offer a comprehensive overview of allergic conjunctivitis.
  • To elucidate the symptoms, classification, and physiopathology of this prevalent allergic disease.
  • To discuss recent advancements in the treatment of allergic conjunctivitis.

Summary:

  • Ocular surface inflammation in allergic conjunctivitis triggers symptoms like itching, tearing, edema, redness, and photophobia.
  • Chronic forms, particularly vernal keratoconjunctivitis, can lead to corneal lesions and visual impairment.
  • The late-phase response involves eosinophilia and neutrophilia, with potential for ocular surface tissue remodeling.

Impact:

  • Enhances understanding of allergic conjunctivitis for clinicians and researchers.
  • Provides a foundation for improved diagnostic and therapeutic strategies.
  • Contributes to better management of allergic eye disease, especially in pediatric populations.

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