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Mucocutaneous findings in 100 children with Down syndrome

Maryam Daneshpazhooh1, T Mohammad-Javad Nazemi, Leyla Bigdeloo

  • 1Department of Dermatology, RAZI Hospital, Tehran University of Medical Sciences, Tehran, Iran. maryamdanesh@yahoo.com

Pediatric Dermatology
|June 5, 2007
PubMed

Insights

This study examined mucocutaneous findings in 100 children with Down syndrome (DS). The most common findings included tongue abnormalities and premature graying, highlighting the need for physician awareness of skin manifestations in DS.

Area of Science:

  • Dermatology
  • Genetics
  • Pediatrics

Background:

  • Down syndrome (DS) is a common chromosomal abnormality impacting multiple organs, including the skin.
  • Mucocutaneous manifestations are frequently observed in individuals with DS.
  • Understanding these findings is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate the prevalence and types of mucocutaneous findings in children with Down syndrome.
  • To document common skin and mucosal lesions associated with DS.
  • To increase physician awareness of dermatological aspects in DS.

Main Methods:

  • A cross-sectional study involving 100 children diagnosed with Down syndrome.
  • Participants aged 3-20 years were recruited from educational and rehabilitation centers in Iran.
  • Clinical examination focused on identifying and documenting skin and mucosal lesions.

Main Results:

  • Mucocutaneous findings were present in 61% of the participants.
  • The most frequent findings included fissured tongue (28%), papillary hypertrophy (22%), and premature graying (14%).
  • Other notable findings were cheilitis (13%), xerosis (12%), and alopecia areata (11%).

Conclusions:

  • Children with Down syndrome frequently exhibit specific mucocutaneous findings, notably tongue abnormalities and premature graying.
  • The absence of atopic dermatitis and infections may be linked to improved hygiene and care.
  • Increased physician awareness of these dermatological signs is essential for managing individuals with Down syndrome.

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