Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amygdala dysfunction in narcolepsy-cataplexy.

Ramin Khatami1, Steffen Birkmann, Claudio L Bassetti

  • 1Department of Neurology, University Hospital, Zürich, Switzerland.

Journal of Sleep Research
|June 5, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

iSPHYNCS: Unsupervised Clustering in Questionnaires and Metadata Reveals Distinct Subtypes in the Narcolepsy Borderland.

Journal of sleep research·2026
Same author

Effect of electronic nicotine delivery systems for smoking cessation on sleep quality: secondary analysis of a randomized controlled trial.

Sleep·2026
Same author

Beyond conventional polysomnography: advanced sleep feature engineering and machine learning for differentiating central disorders of hypersomnolence.

Sleep·2026
Same author

[Impact of malnutrition and sarcopenia on the outcomes of pulmonary rehabilitation in patients with COPD].

Pneumologie (Stuttgart, Germany)·2025
Same author

Most prominent challenges in translational neuroscience and strategic solutions to bridge the gaps: Perspectives from an editorial board interrogation.

Exploration of neuroscience·2025
Same author

Age at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years.

Journal of sleep research·2025
Same journal

Postmortem Evidence of CRH Neuron Reduction in Narcolepsy Without Cataplexy With Borderline Hypocretin-1 Levels.

Journal of sleep research·2026
Same journal

Continuous Positive Airway Pressure Versus Mandibular Advancement Devices Impact on Cardio-Metabolic Outcomes in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Journal of sleep research·2026
Same journal

Strong and Weak Episodic Memories Are Shaped by Multiple Cycles of NREM Spindles and REM Alpha Bursts.

Journal of sleep research·2026
Same journal

A Systematic Review and Meta-Analysis of Biological Sex Differences in Sleep Spindles and Slow Wave Activity in Adults With and Without Insomnia.

Journal of sleep research·2026
Same journal

Thoracoabdominal Asynchrony in Healthy Children.

Journal of sleep research·2026
Same journal

Chronotype and Time of Day Effects in Oddball Task Performance: Behavioural and Cerebral Correlates.

Journal of sleep research·2026
See all related articles

Patients with narcolepsy-cataplexy exhibit normal acoustic startle reflex (ASR) but lack potentiation during unpleasant stimuli. This suggests amygdala dysfunction in narcolepsy-cataplexy, impacting emotional responses.

Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Psychophysiology

Background:

  • The acoustic startle reflex (ASR) blink response is modulated by emotional states.
  • Amygdala lesions in humans result in a loss of aversive ASR potentiation.
  • Narcolepsy-cataplexy (NC) is a neurological disorder affecting sleep-wake cycles.

Purpose of the Study:

  • To investigate the acoustic startle reflex (ASR) modulation in patients with narcolepsy-cataplexy (NC).
  • To determine if NC patients exhibit altered aversive ASR potentiation, suggesting amygdala involvement.

Main Methods:

  • Assessed acoustic startle reflex (ASR) responses in patients diagnosed with narcolepsy-cataplexy.
  • Measured startle potentiation during exposure to unpleasant stimuli in NC patients and controls.

Related Experiment Videos

Main Results:

  • Patients with narcolepsy-cataplexy demonstrated normal baseline ASR.
  • NC patients failed to show the typical increase in ASR (potentiation) when exposed to unpleasant stimuli.
  • This lack of aversive ASR potentiation was observed in the absence of amygdala lesions.

Conclusions:

  • The findings support the hypothesis of amygdala dysfunction in narcolepsy-cataplexy.
  • Altered emotional modulation of the startle reflex may be a characteristic of NC.
  • This research highlights a potential psychophysiological marker for NC.