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Updated: Jul 14, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Bad expression influences time to androgen escape in prostate cancer

Katy Teo1, Lisa Gemmell, Rono Mukherjee

  • 1University of Glasgow, Division of Cancer Sciences and Molecular Pathology, Glasgow, Strathclyde, UK.

BJU International
|June 5, 2007
PubMed
Abstract

Insights

High Bad expression in prostate cancer predicts longer time to relapse and better survival. Pro-apoptotic proteins Bad and Bax decrease as cancer progresses to androgen-independent prostate cancer (AIPC).

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Androgen-deprivation therapy is standard for advanced prostate cancer.
  • Patients often relapse, progressing to androgen-independent prostate cancer (AIPC).
  • Bcl-2 family proteins regulate apoptosis and are implicated in cancer progression.

Purpose of the Study:

  • To investigate the role of Bcl-2 family members (Bad, Bax, Bcl-2, Bcl-xL) in AIPC development.
  • To correlate their expression with clinical outcomes.

Main Methods:

  • Retrospective analysis of 58 prostate cancer patients.
  • Immunohistochemical analysis of matched androgen-dependent (AD) and AIPC tumors.
  • Weighted-histoscore method for staining evaluation.

Main Results:

  • High Bad expression in AD tumors correlated with increased time to biochemical relapse (P=0.007) and a trend towards improved survival (P=0.053).
  • Trends indicated decreased Bad (P=0.068) and Bax (P=0.055) expression during progression to AIPC.
  • No significant associations were found for Bcl-2 or Bcl-xL.

Conclusions:

  • Bad expression at diagnosis may serve as a prognostic marker for time to relapse and overall survival in prostate cancer.
  • Decreased levels of pro-apoptotic proteins Bad and Bax are observed during AIPC development.
  • Bad presents a potential therapeutic target for AIPC.

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