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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Plasma resistin is increased in patients with unstable angina
Wen-lan Hu1, Shu-bin Qiao, Qing Hou
1Department of Cardiology, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chinese Medical Journal
|June 5, 2007
Summary
Plasma resistin levels are significantly elevated in patients with unstable angina compared to stable angina and healthy controls. These findings suggest resistin
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Immunology
Background:
- Resistin, an adipokine implicated in insulin resistance and atherosclerosis, is primarily macrophage-derived.
- Elevated resistin levels are associated with coronary artery disease (CAD), but data in Chinese populations across different CAD stages are limited.
- This study investigates resistin levels in Chinese patients with varying stages of angina.
Purpose of the Study:
- To compare plasma resistin concentrations between patients with unstable angina pectoris (UAP) and stable angina pectoris (SAP).
- To explore the relationship between resistin levels and markers of inflammation and endothelial function in CAD patients.
Main Methods:
- Plasma resistin levels were quantified using enzyme-linked immunosorbent assay (ELISA).
- Participants included 46 patients with UAP, 37 with SAP, and 31 healthy controls.
- Correlations between resistin and leukocyte count, hs-CRP, and endothelin-1 were analyzed.
Main Results:
- Plasma resistin concentrations were significantly higher in the UAP group compared to SAP and control groups.
- No significant difference in resistin levels was observed between the SAP and control groups.
- Plasma resistin positively correlated with leukocyte counts, hs-CRP, and endothelin-1 after adjusting for age, sex, and BMI.
Conclusions:
- Resistin may play a role in the pathogenesis of CAD.
- Elevated resistin in UAP suggests its involvement in acute inflammatory processes within the coronary arteries.
- Resistin's correlation with inflammatory markers indicates a link to systemic inflammation and endothelial activation in CAD.
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