Related Experiment Video

Updated: Jul 14, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Ventriculovascular coupling in systolic and diastolic heart failure

Justin M Fox1, Mathew S Maurer

  • 1Clinical Cardiovascular Research Laboratory for the Elderly, Allen Pavilion of New York Presbyterian Hospital, 5141 Broadway, 3 Field West, Room 035, New York, NY 10034, USA.

Current Cardiology Reports
|June 5, 2007
PubMed

Insights

Ventricular mechanics and heart failure (HF) are better understood through pressure-volume analysis. Abnormal ventriculovascular coupling may be a key factor in HF with normal ejection fraction, offering new therapeutic targets.

Area of Science:

  • Cardiology
  • Physiology
  • Biomedical Engineering

Background:

  • Pressure-volume analysis is crucial for understanding ventricular mechanics and heart failure (HF) mechanisms.
  • Ventriculovascular coupling, the interaction between the left ventricle and arterial system, is gaining renewed research interest.
  • Key areas of investigation include heart rate control in systolic HF, blood pressure lability in the elderly, and acute pulmonary edema in HF patients with preserved ejection fraction.

Purpose of the Study:

  • To explore the role of ventriculovascular coupling in the pathophysiology of heart failure.
  • To investigate abnormal ventriculovascular coupling as a potential mechanism in HF with normal ejection fraction.
  • To identify novel therapeutic targets for HF based on improved understanding of ventriculovascular coupling.

Main Methods:

  • Utilized pressure-volume analysis to assess ventricular mechanics.
  • Reviewed recent investigations into heart rate control, blood pressure lability, and pulmonary edema in HF patients.
  • Analyzed the interaction between the left ventricle and the arterial system (ventriculovascular coupling).

Main Results:

  • Pressure-volume analysis has significantly advanced the understanding of ventricular mechanics and heart failure.
  • Recent studies highlight the importance of heart rate control, blood pressure lability, and acute pulmonary edema in specific HF populations.
  • Emerging data indicate that impaired ventriculovascular coupling is implicated in these clinical scenarios.

Conclusions:

  • Abnormal ventriculovascular coupling may represent an additional pathophysiologic mechanism in the development of heart failure with normal ejection fraction.
  • Understanding ventriculovascular coupling offers potential for developing novel therapeutic strategies for heart failure.
  • Further research into ventriculovascular coupling is warranted to elucidate its precise role and therapeutic implications in HF.

More Related Videos

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Assessing Intracardiac Vortices with High Frame-Rate Echocardiography-Derived Blood Speckle Imaging in Newborns07:13

Assessing Intracardiac Vortices with High Frame-Rate Echocardiography-Derived Blood Speckle Imaging in Newborns

Published on: December 22, 2023

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Cardiac Cycle01:29

Cardiac Cycle

The cardiac cycle refers to the sequence of events that occur in the heart from the beginning of one heartbeat to the next. It's characterized by alternating periods of contraction (systole) and relaxation (diastole) of the heart muscles.
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...