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[Hepatitis B infection and primary glomerulonephritis in children].

V I Naumova, M Ilamanov, V G Ivanov

    Pediatriia
    |January 1, 1991
    PubMed
    Summary

    Hepatitis B virus (HBV) infection is prevalent in children with renal diseases, particularly glomerulonephritis. HBV infection negatively impacts treatment outcomes and disease prognosis in pediatric kidney conditions.

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    [PHOTODYNAMIC THERAPY FOR INTRADERMAL METASTASES OF BREAST CANCER USING THE MATRIX LIGHT-EMITTING DIODES APPARATUS LATUS].

    Voprosy onkologii·2015

    Area of Science:

    • Pediatric Nephrology
    • Hepatology
    • Immunology

    Context:

    • Hepatitis B virus (HBV) infection is a global health concern.
    • Renal pathologies in children can be associated with various systemic infections.
    • The impact of HBV on pediatric renal disease requires further elucidation.

    Purpose:

    • To investigate the prevalence of HBV infection in children with renal pathology.
    • To analyze the clinical characteristics and immunological profiles of HBV-infected children with glomerulonephritis and pyelonephritis.
    • To assess the influence of HBV infection on the prognosis and treatment response of pediatric renal diseases.

    Summary:

    • A study of 165 children with renal pathology revealed HBV infection in 69.7% of those with glomerulonephritis and 30.8% with pyelonephritis.
    • HBV infection, indicated by HBs-antigen carriage and persistent hepatitis, was associated with a prognostically unfavorable mixed form of glomerulonephritis in children under 7.
    • HBV-infected patients showed reduced remission rates with immunosuppressive therapy, decreased serum IgG, lower T lymphocyte counts, a reduced helper/suppressor ratio, and increased lymphocytes expressing IL-2 receptors.

    Impact:

    • Highlights the significant role of HBV infection in pediatric renal diseases.
    • Suggests that HBV screening may be crucial for children presenting with kidney conditions.
    • Informs clinical management strategies and prognostic assessments for pediatric glomerulonephritis and pyelonephritis in the context of HBV infection.

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