Related Experiment Video
Updated: Jul 14, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
The patient with recurrent (sub) obstruction due to Crohn's disease
1Department of Gastroenterology, Chaim Sheba Medical Center, Affiliated to the Tel-Aviv University Sackler School of Medicine, Tel-Hashomer 52621, Israel.
Abstract:
Stricturing Crohn's disease (CD) occurs in 12-54% of the CD patient population and is associated with significant morbidity and impaired quality of life. The detailed pathophysiology of stricture formation has not been fully elucidated, but is primarily associated with luminal narrowing secondary to inflammation and the fibrosis that ensues during mucosal healing. The diagnosis of stricturing disease is based on clinical signs and symptoms along with imaging modalities. The advantages and shortcomings of each imaging modality are discussed. Treatment options are based on the differentiation between inflammatory versus fibrous-predominant strictures; whereas the former can potentially be managed with conservative medical treatment, the latter necessitates a mechanical solution through endoscopy or surgery. Indications, contra-indications and success rates of the different therapeutic approaches are discussed.
Related Concept Videos
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease I: Introduction