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Updated: Jul 14, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Inhaled NO as a therapeutic agent.

Kenneth D Bloch¹, Fumito Ichinose, Jesse D Roberts

¹Cardiovascular Research Center and the Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. kdbloch@partners.org

Cardiovascular Research

|June 5, 2007

Summary

Inhaled nitric oxide (NO) effectively reduces pulmonary artery pressure in newborns with pulmonary hypertension. Research also explores its use in premature infants and for systemic conditions like ischemia-reperfusion injury.

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Area of Science:

Pulmonary Medicine
Neonatology
Pharmacology

Background:

Inhaled nitric oxide (NO) was first reported in 1991 to decrease pulmonary artery pressure (PAP) in lambs with experimental pulmonary hypertension (PH).
Subsequent research in animals and humans led to regulatory approvals for inhaled NO in the US (1999) and Europe (2001).
Inhaled NO is currently indicated for treating neonates with hypoxemia and PH.

Purpose of the Study:

To review the pharmacology and physiological effects of inhaled NO.
To discuss the application of inhaled NO in hypoxemic neonates with PH.
To highlight emerging uses in premature infants and adults with cardiopulmonary disease.

Main Methods:

Literature review of studies on inhaled NO.
Analysis of clinical trials and regulatory approvals.
Summary of pharmacological and physiological data.

Main Results:

Inhaled NO is a selective pulmonary vasodilator, reversing hypoxic pulmonary vasoconstriction.
Studies suggest inhaled NO can prevent chronic lung disease in premature infants.
Unanticipated systemic effects of inhaled NO show potential for treating ischemia-reperfusion injury.

Conclusions:

Inhaled NO is a valuable therapeutic agent for neonatal pulmonary hypertension.
Further research is exploring its efficacy in preventing bronchopulmonary dysplasia and treating adult cardiopulmonary diseases.
Potential applications of inhaled NO's systemic effects are being investigated for various disorders.