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Updated: Jul 14, 2026

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
Published on: January 19, 2014
Alpha-synuclein accumulates in the brain of scrapie-affected sheep and goats
K T Adjou1, S Allix1, M O Ouidja1
1Ecole Nationale Vétérinaire d'Alfort (Laboratoire de Pathologie Médicale du Bétail and Service de Physiologie et Thérapeutique), 7 Avenue du Général de Gaulle, 94 704 Maisons-Alfort, Cedex.
Abstract:
Immunohistochemical examination demonstrated widespread granular deposits of alpha-synuclein (alphaSN) in the brains of sheep and goats with natural scrapie, especially in the cornu ammonis and subiculum of the hippocampus; this contrasted with the diffuse and non-granular immunolabelling seen in healthy controls. There was non-regular "co-localization" of PrP(Sc) and alphaSN. The findings resembled those reported in Creutzfeldt-Jakob disease and in experimental prion disease in hamsters and mice. The results suggest that perturbation of alphaSN metabolism plays a role in human and animal prion diseases.
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