Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The clearance of apoptotic cells by complement.

Roelof Flierman1, Mohamed R Daha

  • 1Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands. r.flierman@lumc.nl

Immunobiology
|June 5, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Carboxypeptidase B2 Gene Polymorphisms With Graft Loss in Kidney Transplantation.

Transplantation direct·2026
Same author

Alternative pathway-mediated tubular complement activation in human proteinuric kidney diseases: a proof-of-concept study.

Clinical kidney journal·2025
Same author

Granzyme K sets complement in motion.

Kidney international·2025
Same author

Complement Activation is More Pronounced in the Kidneys of Critically Ill Patients With COVID-19 Than in Those With Bacterial Sepsis.

Kidney international reports·2025
Same author

C4d, rather than C3d and C5b-9, Is Associated with Graft Loss in Recurrent IgA Deposition after Kidney Transplantation.

American journal of nephrology·2024
Same author

Apical tubular complement activation and the loss of kidney function in proteinuric kidney diseases.

Clinical kidney journal·2024

The complement system aids in clearing apoptotic cells. Its deficiency links to autoimmune diseases like systemic lupus erythematosus (SLE), suggesting a key role in SLE pathogenesis.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • The complement system is crucial for clearing apoptotic cells.
  • Deficiencies in complement components lead to improper handling of apoptotic material.
  • This dysfunction is linked to the development of autoimmune diseases.

Purpose of the Study:

  • To review current data on the complement system and apoptosis.
  • To explore the role of complement in severe autoimmune diseases, particularly systemic lupus erythematosus (SLE).

Main Methods:

  • Literature review of existing studies on complement, apoptosis, and autoimmune diseases.

Main Results:

  • Complement system components are vital for effective apoptotic cell clearance.
  • Impaired complement function contributes to the accumulation of apoptotic material.

Related Experiment Videos

  • This accumulation is associated with the pathogenesis of systemic lupus erythematosus.

    • Conclusions:

    • The complement system plays a significant role in managing apoptotic cells.
    • Dysregulation of the complement system is implicated in the development and progression of systemic lupus erythematosus (SLE).
    • Further research into complement's role may offer therapeutic targets for SLE.