Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mycobacteria and allergies.

Graham A W Rook1, Eckard Hamelmann, L Rosa Brunet

  • 1Centre for Infectious Diseases and International Health, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, 46 Cleveland Street, London W1T 4JF, UK. g.rook@ucl.ac.uk

Immunobiology
|June 5, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Severe asthma and remission prospects in Europe (SHARP): insights from a multicentre observational study based on the European Severe Asthma Registry.

The Lancet. Respiratory medicine·2026
Same author

Update of the evidence- and consensus-based S3 guideline on atopic dermatitis: Systemic therapy with biologics or Janus kinase inhibitors and specific aspects of systemic therapy in pregnancy and lactation.

Allergologie select·2026
Same author

Dupilumab Efficacy in Children With Uncontrolled, Moderate-to-Severe, Type 2 Asthma by Allergen Sensitization Level.

The journal of allergy and clinical immunology. In practice·2026
Same author

Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms.

Nature communications·2026
Same author

[Documentation of biological treatment in asthma].

Pneumologie (Stuttgart, Germany)·2026
Same author

Feasibility, Adherence, Acceptance and Usability of a Multimodal Telemonitoring for Pediatric Post-COVID Syndrome: A Bicentric Pilot Study.

Journal of medical systems·2026
Same journal

ST2-mediated ERK/JNK/P38/NF-κB signaling: a target of Biminkang mixture in minimal persistent inflammation of allergic rhinitis.

Immunobiology·2026
Same journal

Chronic stress promotes colorectal cancer progression by inducing M2 macrophage polarization and activating the CCL2-CCR2 axis.

Immunobiology·2026
Same journal

Spatial-cellular resolution analysis of ferroptosis-associated immune microenvironment heterogeneity in osteoarthritic cartilage.

Immunobiology·2026
Same journal

Exploring therapeutic targets for neuroinflammation in sepsis-associated encephalopathy: a combined network pharmacology and bioinformatics approach.

Immunobiology·2026
Same journal

Potential correlation assessment identified by a genome-wide association study using induced pluripotent stem cells from patients with IgAN.

Immunobiology·2026
Same journal

MicroRNA-5011-5p attenuates LPS-induced inflammatory damage in periodontal ligament cells by targeting KLF6: an in vitro study.

Immunobiology·2026
See all related articles

Mycobacteria exposure may influence allergic disorders. Differentiating between latent tuberculosis (TB) and other exposures is crucial for understanding these effects, as animal models show mycobacteria can modulate allergic responses.

Area of Science:

  • Immunology
  • Microbiology
  • Epidemiology

Background:

  • Mycobacteria are ubiquitous environmental organisms, with some species causing diseases like tuberculosis (TB).
  • Widespread exposure to mycobacteria, including vaccination with Bacillus Calmette-Guérin (BCG), is common globally.
  • Increasing allergic disorders necessitate investigating the role of diverse mycobacterial exposures.

Purpose of the Study:

  • To explore the potential link between mycobacterial exposure and the rise in allergic diseases.
  • To differentiate the immunological impact of latent tuberculosis (TB) from other mycobacterial exposures.
  • To analyze the role of mycobacteria in modulating immune responses relevant to allergies.

Main Methods:

  • Review of existing literature on mycobacterial exposure and allergic disorders.

Related Experiment Videos

  • Analysis of immune response mechanisms, including Th1 and regulatory T cell (RegT) induction.
  • Examination of animal model data and human clinical trial outcomes.

    • Main Results:

    • Animal models demonstrate that mycobacteria can both prevent and treat allergic responses.
    • Mycobacteria-induced immune modulation involves boosting Th1 responses or driving allergen-specific regulatory T cells (RegT).
    • Clinical trial results in humans regarding mycobacteria and allergies remain inconclusive.

    Conclusions:

    • Distinguishing between latent TB and other mycobacterial exposures is essential for understanding their effects on allergies.
    • Further research is needed to clarify the role of mycobacteria in human allergic diseases.
    • Mycobacterial interactions with the immune system offer potential insights into allergy prevention and treatment.