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Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Published on: July 26, 2017
Immunobiology of toll-like receptors in allergic disease
Stefan Bauer1, Doris Hangel, Philipp Yu
1Institut für Immunologie, Philipps-Universität Marburg, BMFZ, Hans-Meerweinstr. 2, 35043 Marburg, Germany. stefan.bauer@staff.uni-marburg.de
Abstract:
Allergic diseases prevalence rates have increased dramatically over the last 50 years in developed countries and one explanation might be that modern practices in public health lead to a decreased exposure towards pathogens resulting in a misguided immune response. Recently, it has become evident that immune responses against pathogens are initiated by Toll-like receptors (TLRs) that recognize a variety of structures derived from viruses, bacteria, fungi or protozoa. In this review we will discuss TLR ligands, TLR signaling in regard to Th1 and Th2 immune responses, their involvement in the development and their therapeutic potential in treatment of allergic disease.
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