Related Experiment Video
Updated: Jan 20, 2026
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
[Expression of hypoxia-inducible factor-1alpha in endometriosis]
Xu Ren1, Yuan-li He, Shi-lei Pan
1Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. renxu@fimmu.com
Objective:
To detect the expression of hypoxia-inducible factor-1alpha(HIF-1alpha) in endometriosis and explore the possible role of HIF-1alpha in the pathogenesis of endometriosis.
Methods:
Immunohistochemistry was performed to examine the expression of HIF-1alpha in 20 normal endometrium, 20 ectopic endometrium and 68 eutopic endometrium specimens from 68 endometriosis patients, and the results were analyzed statistically.
Results:
The expression of HIF-1alpha was significantly increased in ectopic endometrium than in normal endometrium (P<0.01), and the expression did not undergo changes with the normal menstrual cycle in the three types of endometrium.
Conclusion:
HIF-1alpha expression increases in ectopic endometrium, suggesting that HIF-1alpha plays an important role in the pathogenesis of endometriosis.
Related Concept Videos
06:43Imaging Brain Damage Induced by Cerebral Hypoxia-Ischemia in a Mouse Model
07:12A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:53Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
08:51Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling
07:01Induction and Testing of Hypoxia in Cell Culture
02:42Inducing Thrombotic Stroke Through Hypoxia and Ischemia in a Mouse Model