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Updated: May 1, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
[Phase IIa clinical trail of hemocoagulase acutus for injection]
Jun-jie Zhou1, Zong-hai Huang, Jin-long Yu
1Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. tiandansun@21cn.com
Objective:
To evaluate the efficacy and safety of hemocoagulase acutus for injection and determine its curative dose.
Methods:
Forty-five patients on abdominal surgeries were randomly allocated into 2 study groups and 1 control group. Thirty minutes before the operation, the patients in the study groups received intravenous hemocoagulase acutus at 1 U and 2 U, respectively, and control group had no treatment. The hemostatic time, hemorrhagic volume, and hemoagglutination were observed in all the groups.
Results:
The average hemorrhagic volume and hemorrhagic volume per square were significantly lower in the two study groups than in the control group (P<0.05), and the average hemorrhagic volume per square were significantly lower in study group 2 U than in the 1 U group (P<0.05). No significant differences were found in adverse effects between the 3 groups.
Conclusion:
Hemocoagulase acutus for injection has good hemostatic effect for controlling capillary hemorrhage at the abdominal incisions and can be safely used in the surgical patients.
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