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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

OMA Browser--exploring orthologous relations across 352 complete genomes.

Adrian Schneider¹, Christophe Dessimoz, Gaston H Gonnet

¹Institute of Computational Science, ETH Zurich, Switzerland. schneadr@inf.ethz.ch

Bioinformatics (Oxford, England)

|June 5, 2007

Summary

The OMA Browser tool allows exploration of evolutionary protein relationships across 352 genomes. It visualizes orthologous groups and sequence pairs, distinguishing one-to-one, one-to-many, and many-to-many orthologs.

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Area of Science:

Comparative genomics
Bioinformatics
Evolutionary biology

Background:

Identifying orthologs is crucial for understanding protein evolutionary relationships.
Large-scale projects like the Orthologous MAtrix (OMA) project address this challenge.
The OMA project provides a foundation for exploring orthologous relations.

Purpose of the Study:

To introduce the OMA Browser, a web-based tool for exploring orthologous relations.
To facilitate the investigation of evolutionary links between proteins across numerous species.
To provide a user-friendly interface for accessing and visualizing ortholog data.

Main Methods:

Leveraging data from the OMA project.
Developing a web-based application (OMA Browser).
Implementing visualization methods for orthologous groups and sequence pairs.

Main Results:

The OMA Browser enables exploration of orthologous relations across 352 complete genomes.
Users can view orthologs as groups across species or as sequence pairs.
The tool distinguishes between one-to-one, one-to-many, and many-to-many orthologs.

Conclusions:

The OMA Browser is a valuable resource for comparative genomics research.
It enhances the accessibility and usability of ortholog data.
Facilitates deeper insights into protein evolution and function.