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Updated: Jul 14, 2026
09:45
Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
Published on: March 31, 2015
Myc goes global: new tricks for an old oncogene.
1Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, University of California Davis School of Medicine, Davis, California 95616, USA. knoepfler@ucdavis.edu
Cancer Research
|June 5, 2007
Summary
Myc, a key cancer-driving transcription factor, may impact tumors by globally regulating chromatin structure, not just specific genes. This challenges previous understandings of its role in tumorigenesis.
Area of Science:
- Oncology
- Molecular Biology
- Epigenetics
Background:
- Myc is a transcription factor frequently deregulated in cancer.
- Myc's role in tumorigenesis is complex due to its weak action at many target loci and broad regulation of cellular genes (10-15%).
Purpose of the Study:
- To investigate the global regulatory mechanisms of Myc beyond its traditional role as a targeted gene regulator.
- To provide a new perspective on how Myc drives cancer progression.
Main Methods:
- The study analyzed the global effects of Myc on chromatin structure.
- Investigated Myc's regulatory actions at a broader genomic level.
Main Results:
- Myc was found to regulate chromatin structure in a global manner.
- This global regulation extends beyond the regulation of individual target genes.
Conclusions:
- Myc's function in cancer may involve widespread modulation of chromatin structure.
- This challenges the traditional view of Myc as solely a targeted gene regulator, suggesting a more global role in tumorigenesis.
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