Related Experiment Video
Updated: Jul 14, 2026
07:01
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Refractory hiccup: successful treatment with gabapentin
Hortensia Alonso-Navarro1, Lluisa Rubio, Félix Javier Jiménez-Jiménez
1Sección de Neurología, Hospital Virgen de la Concha, Zamora, Spain.
Clinical Neuropharmacology
|June 5, 2007
Summary
This case report highlights gabapentin as a potential treatment for intractable hiccups. The patient experienced significant relief from chronic hiccups after gabapentin administration.
Area of Science:
- Neurology
- Pharmacology
Background:
- Intractable hiccups present a significant clinical challenge.
- Limited effective treatment options exist for chronic or refractory hiccups.
Observation:
- A 69-year-old woman with a 50-year history of refractory hiccups experienced dramatic improvement.
- Improvement occurred during a trial of gabapentin, initially prescribed for essential tremor.
Findings:
- Hiccups recurred upon gabapentin withdrawal.
- Reintroduction of gabapentin led to renewed symptom improvement.
Implications:
- Gabapentin demonstrates potential as a therapeutic agent for refractory hiccups.
- Further investigation into gabapentin's efficacy and mechanism in hiccup management is warranted.
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