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Serum ferritin and obstructive coronary artery disease: angiographic correlation
Moacir Fernandes de Godoy1, Isabela Thomaz Takakura, Rafael Dinardi Machado
1Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil. mfgodoy@netsite.com.br
Arquivos Brasileiros De Cardiologia
|June 5, 2007
Summary
Serum ferritin levels may indicate obstructive coronary artery disease severity in women. Higher ferritin levels (>80 ng/mL) were associated with more severe disease in women, but not in men.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Serum ferritin is a primary iron storage protein.
- Elevated serum ferritin levels have been implicated in various cardiovascular diseases.
Purpose of the Study:
- To investigate the association between serum ferritin levels and the severity of obstructive coronary artery disease (CAD).
Main Methods:
- Coronary arteriography and serum ferritin levels were assessed in 115 patients.
- Cut-off values for serum ferritin were set at 80 ng/ml for women and 120 ng/ml for men.
Main Results:
- While mean ferritin levels differed between sexes, no overall correlation was found between ferritin levels and CAD severity.
- However, women with serum ferritin > 80 ng/mL showed significantly higher odds of moderate to severe obstructive CAD (OR 9.71).
- No significant association was observed for men using their respective cut-off values.
Conclusions:
- Serum ferritin levels > 80 ng/mL are associated with more severe obstructive coronary artery disease in women.
- Serum ferritin is not a predictive element for obstructive coronary artery disease severity in men.
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