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Updated: Jul 14, 2026
Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro
Published on: June 20, 2018
[Expression of Survivin and its significance in tongue squamous cell carcinoma]
Zhi-ming Wang1, Fang Liu, Xin-ming Guan
1Department of Stomatology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China. w_eve@sina.com
Purpose:
To investigate the expression of Survivin,one of inhibitors of apoptosis proteins(IAPs) in tongue squamous cell carcinoma(TSCC), and discuss its clinical significance.
Methods:
Immunohistochemical staining was employed to detect the expression of Survivin in 10 normal lingual mucosal membranes, 13 highly differentiated SCCs,20 medium-differentiated SCCs and 12 low-differentiated SCCs. Data was analyzed with SPSS13 software package for nonparametric Kruskal-Wallis test and Mann-Whitney U test.
Results:
The positive staining rate of Survivin in TSCC was 68.9%, and significantly higher than that in normal control group (P<0.01). Overexpression of Survivin was related to the pathological grade, TNM stage (P<0.05) and closely to lymph node metastasis of TSCC (P<0.01).
Conclusions:
The positive staining of Survivin increased in different grades of TSCC, and Survivin is relative to carcinogenesis, progression and prognosis of TSCC. It may be a new clinical therapeutic target for TSCC.
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