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Designing Porous Silicon Films as Carriers of Nerve Growth Factor
Published on: January 25, 2019
Mesoporous silicon in drug delivery applications
Jarno Salonen1, Ann M Kaukonen, Jouni Hirvonen
1Department of Physics, University of Turku, FI-20014 Turku, Finland.
Journal of Pharmaceutical Sciences
|June 5, 2007
Summary
Mesoporous silicon (PSi) offers tunable pore sizes and surface chemistry for controlled drug release. This material enables room-temperature loading of sensitive therapeutics like peptides and proteins for biomedical applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Mesoporous materials show promise for drug delivery.
- Mesoporous silicon (PSi) possesses advantageous properties for drug delivery applications.
Purpose of the Study:
- To review the fabrication and chemical modifications of mesoporous silicon (PSi) for biomedical applications.
- To highlight the potential advantages of PSi in drug delivery.
Main Methods:
- Fabrication of mesoporous silicon.
- Chemical modification of pore surfaces.
- Drug loading studies at room temperature.
Main Results:
- PSi pore size and surface chemistry can be controlled to modulate drug release kinetics.
- Sustained or increased drug release is achievable.
- Room-temperature loading is suitable for sensitive biomolecules like peptides and proteins.
Conclusions:
- Mesoporous silicon is a versatile platform for drug delivery.
- Tunable properties of PSi offer significant advantages for developing advanced therapeutic systems.
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